Tags & Description
Entire δ
What is w.in α locus, so if α locus begins rearranging, T cell becomes α: β? Answer with a single words or term.
DiGeorge Syndrome
________: had underdeveloped /missing thymus as well as immune deficiency.
Clonal deletion
________: if B cells exhaust all possibilities for L- chain recombination, they are signaled to die by apoptosis in bone marrow.
Β chain rearrangements
________: can possibly happen more than once if they start w. downstream.
FDCs
________ provide signal for B cells to finish maturation.
Peripheral tolerance
________: render self- reactive T cells anergic.
Α chain
________ have a lot of V + J segments so they can rearrange many times for productive AND useful rearrangement.
Large pre B cell
________: successfully rearranged Heavy chain.
Small pre B cell
________: rearranging L chain; if κ fails, λ is rearranged.
IgM associates
________ w. Igα and Igβ to form B cell receptor complex 2nd checkpoint.
T cells
________ develop in thymus- Robert Good recognized that ppl w. thymus tumors had immunologic abnormalities.
Exit bone marrow
________ + move to 2nd lymphoid tissues.