Transplant Rejection Mechanisms

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Transplant rejection

Transplant rejection

________ can occur if recipient immune system recognizes donor alloantigens.

Alloantibodies

________ develop after exposure to alloantigens in previous grafts, blood transfusion, or after pregnancy.

Overtime alloantibodies

________ cause inflammation in graft + form immune complexes that are deposited in graft vasculature.

Chronic Rejection

________: occurs many months /years after graft has been placed.

Allograft

________: tissue transplantation between genetically distinct individuals of the same species.

Hyperacute rejection

________: occurs when recipient has pre- existing Ab to alloantigens.

Alloreactive T cells

________ recognize MHC allotypes on donor dendritic as foreign.